Best Time To Take TMG Supplement

  • By Kim Fields

Published: March 25, 2025

If you are new to the buzz created by TMG and are wondering what it's about, you aren't alone. TMG or Trimethylglycine is derived from Amino Acid and is a crystalline alkaloid contained in sugar beets and other plants. Popularly known as betaine or betaine anhydrous is also produced by the human body and has anti-inflammatory properties.

 

Most commonly found in beetroots, it is responsible for a process called methylation, an essential process for all mammals including humans. It is when our body adds a methyl group in the molecules to help them work properly.

 

This helps in making neurotransmitters or chemical messengers in the brain. So, our motivation, focus, pleasure, relaxation, and mood are dependent on TMG.

As more of its benefits come to light, it raises an important question: When is the best time to take TMG for maximum benefits? If you’re unsure about the right dosage, timing, or how to get the most out of this supplement, we have you covered in this blog.

What is the TMG supplement used for?

TMG supplements play a multipurpose role in our body. From being a mood enhancer to facilitating heart health and taking care of liver functions, TMG is known to have it all. Let us take a quick look at the same and gain a better insight.

  • TMG is involved in methionine, a process that involves getting rid of homocysteine, a harmful amino acid responsible for cardiovascular diseases. Our body struggles with the production of methionine as we age and a supplement is a great way to keep up with our bodily needs.
  • It also helps in enhancing our mental health by optimizing our neurotransmitters that help produce serotonin, dopamine, and norepinephrine.  
  • Athletes have been known to use TMG supplements to enhance exercise performance. It is known to help with muscular strength, running speed and so much more.

The Best Time to Take TMG Supplements

Depending on supplements is like relying on your best friend. There is always a comfort, and you can do things your way. But if you want maximum results out of your consumption, you must have a defined routine of your own. But before that you must keep two key things in mind:

 

  • No Immediate Side Effects: While TMG is generally safe, it’s important to avoid overdoing it. Taking too much could have unintended consequences. But don’t worry if you wish to know more about the extent of the side effects, we will talk about TMG side effects in detail in a later section. 
  • Consult Your Healthcare Provider: Before starting any new supplement, especially if you have co-morbidities, make sure to get advice from your doctor.

 

The Timing:

  • Morning vs. Night: The perfect time for your TMG intake can vary. Some people find it works best with food, while others prefer taking it before bed.
  • Best Time to Take TMG: For optimal absorption, experts recommend taking it in the morning, with or without food.

 

If you're considering LifeFuel (our recommended product), we suggest taking it first thing in the morning before breakfast or coffee. The reason? An empty stomach allows for better absorption, helping you get the most out of your TMG benefits.

How much TMG supplement should I take?

You should be always mindful of the dosage of your supplements as for many products even a slight overdose can cause bodily discomfort. We tend to disregard the seriousness of a supplement most of the time owing to its over-the-counter nature. 

 

But we need to remember that not all bodies are the same, especially if you are allergic or have any co-morbidities you will have to be extra careful. Every product comes with a specific dosage instruction with upto 1,000 milligrams as the limit for normal usage.

 

As for Lifefuel, we recommend that you take one scoop (3 grams) with 8-12oz of water for the best results. But, if you have a pre-existing health condition, we advise you to consult a physician first.

TMG Side Effects and Precautions: What You Need to Know

When it comes to supplements, don’t leave anything to speculation. Studies show that when consumed within the recommended limits, TMG supplements are safe and free of side effects. However, you should always be mindful of your personal situation before diving in.

 

Common Side Effects:

  • Digestive Discomfort: Some people may experience nausea, diarrhea, or stomach upset, especially if they go beyond the prescribed dosage.
  • Body Odor Issues: High doses of TMG can lead to the accumulation of trimethylamine, which may cause an unpleasant body odor.

Pregnancy and Breastfeeding:

  • Consult Your Healthcare Provider: Always check with your doctor before starting a TMG regimen if you’re pregnant or breastfeeding.

Conclusion

TMG or Trimethylglycine is one of those multipurpose miracle compounds that does a lot for your body. From supporting heart health, boosting brain function, and even improving athletic performance. But like any supplement, timing, dosage, and precautions matter if you want to get the best results.

 

For most people, TMG is safe and easy to take but if you do not adhere to the prescribed dosage it can lead to digestive issues or even an unusual body odor. That’s why it’s important to pay attention to how your body reacts, stick to the recommended dosage, and check with a doctor if you have any health concerns.

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Frequently Asked Questions

Can TMG help improve athletic performance and endurance?

Yes, TMG is known to improve athletic performance and endurance with enhanced endurance and a reduction in fatigue during high-intensity workouts. It helps in the conversion of methionine, thereby supporting cardiovascular health, which is crucial for optimal athletic performance.

How does TMG support heart health and lower homocysteine levels?

TMG is popularly known to enhance your cardiovascular health as it helps in reducing homocysteine levels. (Homocysteine is an amino acid formed as a byproduct of the body's methylation process. When its levels become too high, it can increase the risk of cardiovascular diseases).

What is the recommended dosage of TMG for beginners?

For those new to Trimethylglycine (TMG) supplementation, it's advisable to start with a lower dosage to assess individual tolerance and response. As a beginner, you can start with 1,000 mg and level up the dosage as instructed. But, if in case you have any pre-existing health conditions, you must consult a healthcare professional before starting your regime.

Can TMG be taken with other supplements like NMN or B vitamins?

Yes, Trimethylglycine (TMG) can be used together with supplements like Nicotinamide Mononucleotide (NMN) and B vitamins. Taking them together may provide optimal benefits. However it is important to consider personal health conditions and seek advice from a healthcare professional before adding them to your routine.

Should I take TMG on an empty stomach or with food for better absorption?

Trimethylglycine (TMG) is water-soluble, allowing for flexible consumption with or without food. So, it is best to rely on the product specifications before starting your dosage. Additionally, you must make sure that you should start with a lower dose to assess your body's response and decide your regime accordingly. 

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