We must always have prior knowledge about dosage, safety, and precautions before adding any supplement to our routine. Let’s break it into simple terms.
Typical Dosage Recommendations
Supplement General Daily Dosage Special Uses
NAC 600-1,800 mg/day (divided doses) Up to 3,000 mg/day under medical supervision
Glutathione 250-1,000 mg/day 1,000-2,000 mg/day, clinical detox or immune protocols
- NAC should be taken once or twice daily with food for liver support supplements.
- Glutathione is best taken in liposomal form on an empty stomach.
Possible Side Effects
It is illogical to say, if something is natural, then it doesn't have any side effects. The following are the differences between NAC and glutathione in terms of safety.
Supplement Common Side Effects Less Common/Serious
NAC Nausea, headache, Low blood pressure, rash, or gastrointestinal upset, flatulence bronchospasm in sensitive individuals
Glutathione Mild bloating, cramping, and Possible sulfur smell in breath/urine, allergic reactions in rare cases caution with IV use
- NAC is well-tolerated. High doses may lead to digestive issues or lightheadedness.
- Glutathione is safe for most. People with sulfur allergies should be cautious.
Precautions & Drug Interactions
Both NAC and glutathione are potent oxidative stress fighters. They may interact with certain medications.
NAC Precautions:
- May interact with nitroglycerin. May cause headaches or low blood pressure.
- Can thin mucus and blood. Not ideal to take if you’re on blood thinners.
- Avoid taking it right before bedtime.
Glutathione Precautions:
- Generally safe. IV forms should only be administered by professionals.
- It may impact the processing of some drugs by the liver. If you’re on chemotherapy or immunosuppressants, consult your doctor.